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Access through your institution Buy or subscribe The efficacy of vaccination can be impaired considerably by even a mild coinfection; many and often conflicting reasons have been proposed
for this phenomenon. Welsh and colleagues, in the _Journal of Virology_, use mice transgenic for a T cell antigen receptor specific for the male HY antigen or for virus peptide to determine
how viral coinfection perturbs responses. Simultaneous triggering of HY- and virus-specific T cells results in robust responses by both populations; however, if the stimulation of
HY-specific T cells is delayed by a few days, the responses to this antigen are lower. The possibility of activation-induced cell death or active killing by death receptors is ruled out;
instead, the impairment coincides with the peak of virus-induced type I interferon (IFN-α or IFN-β). Indeed, interferon stimulators such as poly(I:C) also impair the response of bystander
HY-specific T cells much like viral infection, but not if the cells lack the receptor for type I interferon. These findings have important implications for the effective generation of
vaccine and memory responses. _ZF_ _J. Virol._ (6 April 2011) doi:10.1128/JVI.02516-10 This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through
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Read our FAQs * Contact customer support RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Research Highlights. _Nat Immunol_ 12, 518 (2011).
https://doi.org/10.1038/ni0611-518 Download citation * Published: 18 May 2011 * Issue Date: June 2011 * DOI: https://doi.org/10.1038/ni0611-518 SHARE THIS ARTICLE Anyone you share the
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