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IAPP, a hormone secreted together with insulin and deposited in pancreatic islets in type 2 diabetes, can induce macrophage processing of interleukin 1 linked to beta-cell destruction in
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Contact customer support CHANGE HISTORY * _ 21 OCTOBER 2010 In the version of this article initially published, some of the text on p 882 was inaccurate. The correct text should read as
follows: “thereby counteracting the beneficial effects of blocking IAPP on islet inflammation” (middle column) and “This mechanism has been suggested to mediate ROS-dependent inflammasome
activation induced by high concentrations of glucose in mouse pancreatic beta cells12, although this finding is now being debated” (right column, first full paragraph, second sentence). The
errors have been corrected in the HTML and PDF versions of the article. _ REFERENCES * Kolb, H. & Mandrup-Poulsen, T. _Diabetologia_ 48, 1038–1050 (2005). Article CAS PubMed Google
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Scholar * Zhou, R. et al. _Nat. Immunol._ 11, 136–140 (2010). Article CAS PubMed Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Thomas Mandrup-Poulsen
is in the Department for Biomedical Sciences, Denmark and the Department of Medicine and Surgery, University of Copenhagen, Copenhagen, the Hagedorn Research Institute, Gentofte, Karolinska
Institutet, Stockholm, Sweden., Thomas Mandrup-Poulsen Authors * Thomas Mandrup-Poulsen View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING
AUTHOR Correspondence to Thomas Mandrup-Poulsen. ETHICS DECLARATIONS COMPETING INTERESTS T.M.-P. is a part-time employee of and owns shares in Novo Nordisk. RIGHTS AND PERMISSIONS Reprints
and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mandrup-Poulsen, T. IAPP boosts islet macrophage IL-1 in type 2 diabetes. _Nat Immunol_ 11, 881–883 (2010).
https://doi.org/10.1038/ni1010-881 Download citation * Issue Date: October 2010 * DOI: https://doi.org/10.1038/ni1010-881 SHARE THIS ARTICLE Anyone you share the following link with will be
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