ABSTRACT Immune-mediated inflammation and allograft rejection are greatly reduced in certain organs, a phenomenon called 'immune privilege'. Immune privilege is well developed in

three regions of the body: the eye, the brain and the pregnant uterus. Immune-mediated inflammation has devastating consequences in the eye and brain, which have limited capacity for

regeneration. Likewise, loss of immune privilege at the maternal-fetal interface culminates in abortion in rodents. However, all three regions share many adaptations that restrict the

induction and expression of immune-mediated inflammation. A growing body of evidence from rodent studies suggests that a breakdown in immune privilege contributes to multiple sclerosis,

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I dedicate this review to the memory of J.W. Streilein, who contributed substantially to the understanding of immune-privileged sites. Supported by Research to Prevent Blindness. AUTHOR

INFORMATION AUTHORS AND AFFILIATIONS * Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390-9057, Texas, USA Jerry Y Niederkorn Authors * Jerry Y

Niederkorn View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Jerry Y Niederkorn. ETHICS DECLARATIONS COMPETING

INTERESTS The author declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Niederkorn, J. See no evil, hear no evil,

do no evil: the lessons of immune privilege. _Nat Immunol_ 7, 354–359 (2006). https://doi.org/10.1038/ni1328 Download citation * Published: 20 March 2006 * Issue Date: 01 April 2006 * DOI:

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