Play all audios:
Access through your institution Buy or subscribe The negative effects of stress on behavior are familiar to many of us. A recent study in _Neuron_ (71, 498–511) discloses a possible
molecular mechanism to account for them. Experimenting on mice, Michael Bruchas _et al_. focused on the serotonergic neurons of the dorsal raphe nuclei—a brain region crucial for
mood-related behaviors. The team selectively knocked out the α isoform of p38 mitogen-activated protein kinase (MAPK)—which regulates stress-dependent responses—from raphe neurons and found
that the mutant mice were more resilient to stress. So, whereas wild-type mice showed depression and increased drug seeking in response to stress, the mice lacking p38α kept their cool in
the face of adversity. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues
and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local
taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Juan Carlos
López View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE López, J.
Stressed out?. _Nat Med_ 17, 1198 (2011). https://doi.org/10.1038/nm.2516 Download citation * Published: 11 October 2011 * Issue Date: October 2011 * DOI: https://doi.org/10.1038/nm.2516
SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to
clipboard Provided by the Springer Nature SharedIt content-sharing initiative