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Metastatic colorectal cancer is a largely incurable disease with a pressing need for targeted therapies. A new study sheds light on a surprising interaction between FOXO3a and β-catenin in
metastatic colorectal cancer, suggesting new therapeutic avenues for agents targeting the PI3K-AKT pathway (pages 892–901). Access through your institution Buy or subscribe This is a preview
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checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Howlader, N. et al. SEER Cancer Statistics
Review. National Cancer Institute, Bethesda, MD (2008). * Samuels, Y. & Velculescu, V.E. _Cell Cycle_ 3, 1221–1224 (2004). Article CAS PubMed Google Scholar * Zhang, Y., Gan, B.,
Liu, D. & Paik, J.H. _Cancer Biol. Ther._ 12, 253–259 (2011). Article CAS PubMed Google Scholar * Yang, J.Y. & Hung, M.C. _Curr. Drug Targets_ 12, 1284–1290 (2011). Article CAS
PubMed PubMed Central Google Scholar * Tenbaum, S.P. et al. _Nat. Med._ 18, 892–901 (2012). Article CAS PubMed Google Scholar * Aberle, H., Bauer, A., Stappert, J., Kispert, A.
& Kemler, R. _EMBO J._ 16, 3797–3804 (1997). Article CAS PubMed PubMed Central Google Scholar * Dehner, M., Hadjihannas, M., Weiske, J., Huber, O. & Behrens, J. _J. Biol. Chem._
283, 19201–19210 (2008). Article CAS PubMed Google Scholar * Biechele, T.L. et al. _Sci. Signal. 5_, ra3 (2012). * Yang, J.Y. et al. _Nat. Cell Biol._ 10, 138–148 (2008). Article CAS
PubMed PubMed Central Google Scholar * Wallin, J.J. et al. _Mol. Cancer Ther._ 10, 2426–2436 (2011). Article CAS PubMed Google Scholar * Huang, S.M. et al. _Nature_ 461, 614–620
(2009). Article CAS PubMed Google Scholar * Rojo, F., et al. _J. Clin. Oncol._ 24, 4309–4316 (2006). Article CAS PubMed Google Scholar * Ciardiello, F. & Tortora, G. _N. Engl. J.
Med._ 358, 1160–1174 (2008). Article CAS PubMed Google Scholar * Brabletz, T. et al. _Proc. Natl. Acad. Sci. USA_ 98, 10356–10361 (2001). Article CAS PubMed PubMed Central Google
Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Yibing Yan and Mark R. Lackner are in the Department of Oncology Biomarker Development, Genentech, South San
Francisco, California, USA., Yibing Yan & Mark R Lackner Authors * Yibing Yan View author publications You can also search for this author inPubMed Google Scholar * Mark R Lackner View
author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Yibing Yan or Mark R Lackner. ETHICS DECLARATIONS COMPETING INTERESTS
The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Yan, Y., Lackner, M. FOXO3a and β-catenin
co-localization: double trouble in colon cancer?. _Nat Med_ 18, 854–856 (2012). https://doi.org/10.1038/nm.2799 Download citation * Published: 06 June 2012 * Issue Date: June 2012 * DOI:
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