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Access through your institution Buy or subscribe To the Editor: We read with great interest the recent article in _Nature Medicine_ by Saito et al.1 describing the role of hypoxia-inducible
factor-2α (HIF-2α) in skeletal growth and osteoarthritis development. The authors report that HIF-2α is a central transactivator targeting several crucial genes for endochondral ossification
in mice1. The role of HIF-2α in human osteoarthritis is buttressed by their Japanese association study suggesting that rs17039192, a functional single nucleotide polymorphism (SNP) in the
human _EPAS1_ gene encoding HIF-2α, is associated with knee osteoarthritis1. Although the study clearly contains interesting and compelling data on the effect of HIF-2α in endochondral
ossification during skeletal growth in mice, the human evidence, supporting the role of HIF-2α in osteoarthritis, is limited by its small sample size and a marginal _P_ value. Given that
lack of replication and false positive findings are common pitfalls of association studies2, we sought to further clarify the association of the HIF-2α SNP rs17039192 with osteoarthritis.
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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Saito, T. et al. _Nat. Med._
16, 641–644 (2010). Article Google Scholar * Ikegawa, S. _Curr. Opin. Rheumatol._ 19, 429–434 (2007). Article Google Scholar * Miyamoto, Y. et al. _Nat. Genet._ 39, 529–533 (2007).
Article CAS Google Scholar * Nakajima, M. et al. _PLoS One_ 18, e9723 (2010). Article Google Scholar * Shi, D. et al. _Osteoarthritis Cartilage_ 18, 1454–1457 (2010). Article CAS
Google Scholar * Yang, S. et al. _Nat. Med._ 16, 687–693 (2010). Article CAS Google Scholar Download references AUTHOR INFORMATION Author notes * Masahiro Nakajima and Dongquan Shi:
These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan Masahiro Nakajima, Jin Dai
& Shiro Ikegawa * The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China Dongquan Shi, Jin Dai
& Qing Jiang * Laboratory for Bone and Joint Diseases, Model Animal Research Center, Nanjing University, Nanjing, China Dongquan Shi, Shiro Ikegawa & Qing Jiang * Laboratory of
Cytogenetics and Molecular Genetics, Medical School, University of Thessaly, Larissa, Greece Aspasia Tsezou * School of Surgery, University of Western Australia, Perth, Australia Minghao
Zheng, Paul E Norman & Shiro Ikegawa * Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo, Japan Atsushi Takahashi Authors * Masahiro Nakajima View author
publications You can also search for this author inPubMed Google Scholar * Dongquan Shi View author publications You can also search for this author inPubMed Google Scholar * Jin Dai View
author publications You can also search for this author inPubMed Google Scholar * Aspasia Tsezou View author publications You can also search for this author inPubMed Google Scholar *
Minghao Zheng View author publications You can also search for this author inPubMed Google Scholar * Paul E Norman View author publications You can also search for this author inPubMed
Google Scholar * Atsushi Takahashi View author publications You can also search for this author inPubMed Google Scholar * Shiro Ikegawa View author publications You can also search for this
author inPubMed Google Scholar * Qing Jiang View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Shiro Ikegawa or Qing
Jiang. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY TEXT AND FIGURES Supplementary Fig. 1 and
Supplementary Table 1 (PDF 107 kb) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nakajima, M., Shi, D., Dai, J. _et al._ Replication studies in various
ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis. _Nat Med_ 17, 26–27 (2011). https://doi.org/10.1038/nm0111-26 Download citation *
Published: 07 January 2011 * Issue Date: January 2011 * DOI: https://doi.org/10.1038/nm0111-26 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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