Play all audios:
ABSTRACT Angiogenesis, the growth of new blood vessels, occurs normally in female reproductive organs. We tested the hypothesis that angiogenesis inhibition may affect fertility by studying
the reproductive system in either pregnant or nonpregnant cycling mice after treatment with the angiogenesis inhibitor AGM-1470. Administration of AGM-1470 to pregnant mice resulted in
complete failure of embryonic growth due to interference with decidualization, placental and yolk sac formation, and embryonic vascular development. When nonpregnant cycling female mice were
chronically treated with AGM-1470, inhibition of endometrial maturation and corpora lutea was observed. These data suggest that processes in reproduction can be controlled through
angiogenesis inhibition. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access
to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read
our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EFFECTS OF CIGARETTE SMOKE EXTRACT ON ANGIOGENESIS AND AROMATASE ACTIVITY IN KGN CELLS Article Open access 22 April
2025 PHYSIOLOGICAL PREMATURE AGING OF OVARIAN BLOOD VESSELS LEADS TO DECLINE IN FERTILITY IN MIDDLE-AGED MICE Article Open access 02 January 2025 HALLMARKS OF FEMALE REPRODUCTIVE AGING IN
PHYSIOLOGIC AGING MICE Article 13 December 2024 REFERENCES * Folkman, J. & Klagsbrun, M. Angiogenic factors. _Science_ 235, 442–447 (1987). Article CAS PubMed Google Scholar *
Reynolds, L.P., Killilea, S.D. & Redmer, D.A. Angiogenesis in the female reproductive system. _FASEB J._ 6, 886–892 (1992). Article CAS PubMed Google Scholar * Poole, T.J. &
Coffin, J.D. Vasculogenesis and angiogenesis — two distinct morphogenetic mechanisms establish embryonicvascular pattern. _J. Exp. Zool._ 251, 224–231 (1989). Article CAS PubMed Google
Scholar * Folkman, J. What is the evidence that tumors are angiogenesis dependent? _J. Natl. Cancer Inst._ 82, 4–6 (1989). Article Google Scholar * Michaelson, I.C. The mode of
development of the vascular system of the retina, with some observations on its significance for certain retinal disease. _Trans. Ophthalmol. Soc. UK_ 68 137–180 (1948). Google Scholar *
Engerman, R.L., Pfaffenbach, D. & Davis, M.D. Cell turnover of capillaries. _Lab. Invest._ 17, 738–743 (1967). CAS PubMed Google Scholar * Christenson, L.K. & Stouffer, R.L.
Proliferation of microvascular endothelial cells in the primate corpus luteum during the menstrual cycle and simulated early pregnancy. _Endocrinol._ 137, 367–374 (1996). Article CAS
Google Scholar * Goodger, A.M., Rogers, P.A. Uterine endothelial proliferation before and after embryo implantation. _J. Reprod. Fertility_ 99, 451–457 (1993). Article CAS Google Scholar
* Tamura, H. & Greenwald, G.S. Angiogenesis and its hormonal control in the corpus luteum of the pregnant rat. _Biol. Reprod._ 36, 1149–1154 (1987). Article CAS PubMed Google
Scholar * Welch, A.O. & Enders, A.C. Chorioallantoic placenta formation in the rat: Angiogenesis and maternal blood circulation in the mesometrial region of the implantation chamber
prior to placenta formation. _Am. J. Anat._ 192, 347–365 (1991). Article Google Scholar * Ingber, D. _et al_. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor
growth. _Nature_ 348, 555–557 (1990). Article CAS PubMed Google Scholar * Champlin, A.K., Dorr, D.L. & Gates, A.H. Determining the stage of the estrous cycle in the mouse by the
appearance of the vagina. _Biol. Reprod._ 8, 491–494 (1973). Article CAS PubMed Google Scholar * Schlaeger, T.M., Qin, Y., Fujiwara, Y., Magram, J. & Sato, T.N. Vascular endothelial
cell lineage-specific promoter in transgenic mice. _Development_ 121, 1089–1098 (1995). CAS PubMed Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS *
Department of Surgery, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA Nancy Klauber, Richard M. Rohan, Evelyn Flynn & Robert
J. D'amato * Department of Surgery, Boston University Medical Center, Boston, Massachusetts, 02118, USA Nancy Klauber Authors * Nancy Klauber View author publications You can also
search for this author inPubMed Google Scholar * Richard M. Rohan View author publications You can also search for this author inPubMed Google Scholar * Evelyn Flynn View author publications
You can also search for this author inPubMed Google Scholar * Robert J. D'amato View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Klauber, N., Rohan, R., Flynn, E. _et al._ Critical components of the female reproductive pathway are suppressed by
the angiogenesis inhibitor AGM-1470. _Nat Med_ 3, 443–446 (1997). https://doi.org/10.1038/nm0497-443 Download citation * Received: 11 November 1996 * Accepted: 04 February 1997 * Issue Date:
01 April 1997 * DOI: https://doi.org/10.1038/nm0497-443 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable
link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative