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Atherosclerotic lesions can result in fatal cardiovascular disease, but what triggers the formation of the atheroma plaques and their progression still begs further investigation. In
'Bench to Bedside', Göran K Hansson and Lars Klareskog peruse how the NLRP3 inflammasome can be activated by cholesterol crystals and worsen atherosclerosis by triggering
inflammation through the release of IL-1β from macrophages. But these cells can also die at the lesion site, forming a necrotic core in the atheroma by building up apoptotic cells and
debris. In 'Bedside to Bench', Ira Tabas discusses a human study showing that lesional necrosis along with thinning of the fibrotic cap are predictive of culprit lesions involved
in fatal disease. Understanding the molecular underpinnings of these two morphological features may lead to new therapies to prevent or decrease the risk for major cardiovascular disease.
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references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Göran K. Hansson and Lars Klareskog are in the Department of Medicine and Center for Molecular Medicine, Karolinska Institutet,
Stockholm, Sweden., Göran K Hansson & Lars Klareskog Authors * Göran K Hansson View author publications You can also search for this author inPubMed Google Scholar * Lars Klareskog View
author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Göran K Hansson or Lars Klareskog. ETHICS DECLARATIONS COMPETING
INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hansson, G., Klareskog, L. Pulling down
the plug on atherosclerosis: Cooling down the inflammasome. _Nat Med_ 17, 790–791 (2011). https://doi.org/10.1038/nm0711-790 Download citation * Published: 07 July 2011 * Issue Date: July
2011 * DOI: https://doi.org/10.1038/nm0711-790 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
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