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Access through your institution Buy or subscribe The _ROSA26_ locus in the genome of mouse embryonic stem cells is easy to target and expresses transgenes well. Irion _et al_. identified the
human equivalent of the _ROSA26_ locus on chromosome 3. They integrated various genes into that locus and followed the multilineage differentiation of the targeted cells. Their locus
provides a safe landing spot for transgenes and makes worries about gene silencing or disruption of endogenous genes because of random integration a thing of the past. Irion, S. _et al_.
_Nat. Biotechnol._ 25, 1477–1482 (2007). This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal
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RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE News in brief. _Nat Methods_ 5, 7 (2008). https://doi.org/10.1038/nmeth0108-7 Download citation * Issue
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