Play all audios:
ABSTRACT Small, high-impedance neurons with short processes, similar to those found in the soil nematode _Caenorhabditis elegans_, are predicted to transmit electrical signals by passive
propagation. However, we have found that certain neurons in _C. elegans_ fire regenerative action potentials. These neurons resembled Schmitt triggers, as their potential state appears to be
bistable. Transitions between up and down states could be triggered by application of the neurotransmitter glutamate or brief current pulses. Access through your institution Buy or
subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online
access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which
are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS
NEURAL SIGNAL PROPAGATION ATLAS OF _CAENORHABDITIS ELEGANS_ Article Open access 01 November 2023 _C. ELEGANS_ ENTERIC MOTOR NEURONS FIRE SYNCHRONIZED ACTION POTENTIALS UNDERLYING THE
DEFECATION MOTOR PROGRAM Article Open access 19 May 2022 U(1) DYNAMICS IN NEURONAL ACTIVITIES Article Open access 21 October 2022 REFERENCES * de Bono, M. & Maricq, A.V. _Annu. Rev.
Neurosci._ 28, 451–501 (2005). Article CAS PubMed Google Scholar * Yu, F.H., Yarov-Yarovoy, V., Gutman, G.A. & Catterall, W.A. _Pharmacol. Rev._ 57, 387–395 (2005). Article CAS
PubMed Google Scholar * Goodman, M.B., Hall, D.H., Avery, L. & Lockery, S.R. _Neuron_ 20, 763–772 (1998). Article CAS PubMed PubMed Central Google Scholar * Davis, R.E. &
Stretton, A.O. _Parasitology_ 113 Suppl: S97–S117 (1996). Article PubMed Google Scholar * Raizen, D.M. & Avery, L. _Neuron_ 12, 483–495 (1994). Article CAS PubMed PubMed Central
Google Scholar * Shtonda, B. & Avery, L. _J. Exp. Biol._ 208, 2177–2190 (2005). Article CAS PubMed PubMed Central Google Scholar * Davis, R.E. & Stretton, A.O. _J. Neurosci._
9, 415–425 (1989). Article CAS PubMed Google Scholar * Zheng, Y., Brockie, P.J., Mellem, J.E., Madsen, D.M. & Maricq, A.V. _Neuron_ 24, 347–361 (1999). Article CAS PubMed Google
Scholar * Brockie, P.J., Madsen, D.M., Zheng, Y., Mellem, J. & Maricq, A.V. _J. Neurosci._ 21, 1510–1522 (2001). Article CAS PubMed Google Scholar * Francis, M.M. & Maricq, A.V.
_Methods Mol. Biol._ 351, 175–192 (2006). CAS PubMed Google Scholar * Frokjaer-Jensen, C. et al. _J. Neurobiol._ 66, 1125–1139 (2006). Article CAS PubMed Google Scholar * Humphrey,
J.A. et al. _Curr. Biol._ 17, 624–629 (2007). Article CAS PubMed Google Scholar * Zheng, Y., Mellem, J.E., Brockie, P.J., Madsen, D.M. & Maricq, A.V. _Nature_ 427, 451–457 (2004).
Article CAS PubMed Google Scholar * Gray, J.M., Hill, J.J. & Bargmann, C.I. _Proc. Natl. Acad. Sci. USA_ 102, 3184–3191 (2005). Article CAS PubMed Google Scholar * Loewenstein,
Y. et al. _Nat. Neurosci._ 8, 202–211 (2005). Article CAS PubMed Google Scholar Download references ACKNOWLEDGEMENTS We thank M. Vetter and members of the Maricq laboratory for comments
on the manuscript and the _Caenorhabditis_ Genetic Center, funded by the US National Institutes of Health National Center for Resources, for _C. elegans_ strains. This research was made
possible by support from the US National Institutes of Health (grant NS35812). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Biology, University of Utah, Salt Lake City, Utah,
84112-0840, USA Jerry E Mellem, Penelope J Brockie, David M Madsen & Andres V Maricq Authors * Jerry E Mellem View author publications You can also search for this author inPubMed Google
Scholar * Penelope J Brockie View author publications You can also search for this author inPubMed Google Scholar * David M Madsen View author publications You can also search for this
author inPubMed Google Scholar * Andres V Maricq View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS J.E.M. carried out the
electrophysiological experiments and participated in data analysis. P.J.B. generated strains, participated in data analysis and helped prepare the manuscript. D.M.M. provided molecular
biology expertise and A.V.M. supervised the experiments, participated in data analysis and wrote the manuscript. CORRESPONDING AUTHOR Correspondence to Andres V Maricq. SUPPLEMENTARY
INFORMATION SUPPLEMENTARY TEXT AND FIGURES Supplementary Figures 1 and 2 (PDF 148 kb) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mellem, J.,
Brockie, P., Madsen, D. _et al._ Action potentials contribute to neuronal signaling in _C. elegans_. _Nat Neurosci_ 11, 865–867 (2008). https://doi.org/10.1038/nn.2131 Download citation *
Received: 13 March 2008 * Accepted: 02 May 2008 * Published: 29 June 2008 * Issue Date: August 2008 * DOI: https://doi.org/10.1038/nn.2131 SHARE THIS ARTICLE Anyone you share the following
link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature
SharedIt content-sharing initiative