Play all audios:
A report elucidates the widely recognized, but poorly understood, concept of gene-environment interaction, finding a molecular mechanism in the case of post-traumatic stress disorder:
demethylation of a glucocorticoid response element in the stress response regulator _FKBP5_ that depends on both the risk allele and childhood trauma. Access through your institution Buy or
subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online
access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which
are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Caspi, A. et al.
_Science_ 301, 386–389 (2003). Article CAS Google Scholar * Klengel, T. _Nat. Neurosci._ 15, 33–41 (2012). Google Scholar * Weaver, I.C. et al. _Nat. Neurosci._ 7, 847–854 (2004).
Article CAS Google Scholar * Binder, E.B. et al. _J. Am. Med. Assoc._ 299, 1291–1305 (2008). Article CAS Google Scholar * D'Alessio, A.C., Weaver, I.C. & Szyf, M. _Mol. Cell.
Biol._ 27, 7462–7474 (2007). Article CAS Google Scholar * Szyf, M. _Clin. Genet._ 81, 341–349 (2012). Article CAS Google Scholar * Razin, A. & Szyf, M. _Biochim. Biophys. Acta_
782, 331–342 (1984). Article CAS Google Scholar * Wang, D. et al. _PLoS ONE_ 7, e39501 (2012). Article CAS Google Scholar * Yehuda, R. et al. _Biol. Psychiatry_ 66, 708–711 (2009).
Article CAS Google Scholar * Uddin, M. et al. _Proc. Natl. Acad. Sci. USA_ 107, 9470–9475 (2010). Article CAS Google Scholar * Uddin, M. et al. _Dis. Markers_ 30, 111–121 (2011).
Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Moshe Szyf is in the Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill
University, Montreal, Quebec, Canada., Moshe Szyf Authors * Moshe Szyf View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR
Correspondence to Moshe Szyf. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE
CITE THIS ARTICLE Szyf, M. How do environments talk to genes?. _Nat Neurosci_ 16, 2–4 (2013). https://doi.org/10.1038/nn.3286 Download citation * Published: 21 December 2012 * Issue Date:
January 2013 * DOI: https://doi.org/10.1038/nn.3286 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link
is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative