ABSTRACT Fear conditioning is one of the most widely used animal models for studying the neurobiological basis of fear and anxiety states. Conditioned inhibition of fear (or learned safety),

however, is a relatively unexplored behavioral paradigm addressing the aspect of regulation of fear, which is central to survival and mental health. Although fear conditioning is achieved

by pairing a previously neutral, conditioned stimulus (CS) with an aversive, unconditioned stimulus (US), learned safety training consists of a series of explicitly unpaired CS–US

presentations. Animals are trained for 3 d, one session per day, and learn to associate the CS with protection from the impending danger of the aversive events. The entire procedure can be

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SIMILAR CONTENT BEING VIEWED BY OTHERS DIFFERENTIAL RECRUITMENT OF BRAIN CIRCUITS DURING FEAR EXTINCTION IN NON-STRESSED COMPARED TO STRESS RESILIENT ANIMALS Article Open access 25 January

2024 REFINEMENT OF THE STRESS-ENHANCED FEAR LEARNING MODEL OF POST-TRAUMATIC STRESS DISORDER: A BEHAVIORAL AND MOLECULAR ANALYSIS Article 20 October 2022 SEROTONIN 5-HT2C RECEPTOR KNOCKOUT

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by indoleamine 2,3-dioxygenase. _Nat. Med._ 9, 1269–1274 (2003). Article  CAS  Google Scholar  Download references AUTHOR INFORMATION Author notes * Daniela D Pollak and Francisco J Monje:

These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Department of Physiology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

Daniela D Pollak & Francisco J Monje * Department of Pediatrics, Division of Pediatric Neuroscience, Medical University of Vienna, Vienna, Austria Gert Lubec Authors * Daniela D Pollak

View author publications You can also search for this author inPubMed Google Scholar * Francisco J Monje View author publications You can also search for this author inPubMed Google Scholar

* Gert Lubec View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS D.D.P. jointly conceived the study with F.J.M.; D.D.P. conducted behavioral

experiments; D.D.P. and F.J.M. interpreted and analyzed the data; G.L. and D.D.P. wrote the paper. CORRESPONDING AUTHOR Correspondence to Daniela D Pollak. ETHICS DECLARATIONS COMPETING

INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pollak, D., Monje, F. & Lubec, G. The

learned safety paradigm as a mouse model for neuropsychiatric research. _Nat Protoc_ 5, 954–962 (2010). https://doi.org/10.1038/nprot.2010.64 Download citation * Published: 29 April 2010 *

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