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Access through your institution Buy or subscribe The role of exosomes as mediators between cancer cells and the microenvironment has gained increasing attention. Two studies have provided
further information on the part these small vesicles play in tumour progression and resistance to therapy. Through computational analysis, the pattern recognition receptor RIG-I was
identified as the mediator of fibroblast-induced upregulation of _STAT1_ and IRDS genes. Indeed, knocking down RIG-I in IRDS-Rs inhibited IRDS gene induction and radiation protection in
cancer cells after co-culture with fibroblasts. Conditioned media from IRDS-Rs cultured with fibroblasts upregulated IRDS genes in breast cancer cells, suggesting the presence of a secreted
factor that is capable of activating RIG-I in these cells. The authors found that this paracrine induction of IRDS genes was triggered by an increase in the number of exosomes after
co-culture, which were transferred from stromal cells to breast cancer cells. Further experiments showed that these exosomes contained 5′-triphosphate RNA that can activate RIG-I signalling
in breast cancer cells. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print
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local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES *
Boelens, M. C. et al. Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. _Cell_ 159, 499–513 (2014) Article CAS Google Scholar * Melo, S. A. et
al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. _Cancer Cell_ 26, 707–721 (2014) Article CAS Google Scholar Download references Authors * M.
Teresa Villanueva View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Villanueva, M. Small containers, important cargo. _Nat Rev Cancer_ 14, 764–765 (2014). https://doi.org/10.1038/nrc3864 Download citation * Published: 24 November 2014 * Issue Date: December
2014 * DOI: https://doi.org/10.1038/nrc3864 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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