ABSTRACT The current focus of cardiovascular medicine is on early detection and prevention of disease, to control the escalating costs of health care. To achieve this goal, novel imaging

approaches that allow for early detection of disease and risk stratification are needed. Traditionally, the diagnosis, monitoring, and prognostication of cardiovascular disease were based on

techniques that measured changes in metabolism, blood flow, and biological function. Molecular imaging is emerging as a new tool for the noninvasive detection of biological processes that

can differentiate and characterize tissues before manifestation of gross anatomical features or physiological consequences. Leading the way are techniques involving high-sensitivity

critical molecular processes, such as atherosclerosis, ventricular remodeling after myocardial infarction, and ischemia-associated angiogenesis. KEY POINTS * With the growth of genomics and

proteomics has come a requirement for new diagnostic molecular imaging approaches that advance health care through early detection of disease processes * Noninvasive targeted

radiotracer-based SPECT and PET approaches are evolving through both preclinical imaging studies, involving transgenic animals, and advances in imaging technology * Both SPECT and PET, as

nuclear techniques, have unique advantages including high sensitivity and selectivity, which make these approaches particularly suitable for cardiovascular molecular imaging * The

introduction of hybrid SPECT–CT and PET–CT imaging systems has greatly enhanced the performance and accuracy of nuclear imaging * The examples of targeted radiotracer imaging with SPECT and

PET presented in this Review provide insight into the future of noninvasive cardiovascular imaging Access through your institution Buy or subscribe This is a preview of subscription content,

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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS IMAGING OF ATHEROSCLEROSIS WITH

[64CU]CU-DOTA-TATE IN A TRANSLATIONAL HEAD-TO-HEAD COMPARISON STUDY WITH [18F]FDG, AND NA[18F]F IN RABBITS Article Open access 07 June 2023 UNCOVERING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

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Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medicine and Department of Diagnostic Radiology, Section of Cardiovascular Medicine, Yale University School of

Medicine, P. O. Box 208017, New Haven, 06520-8017, CT, USA Lawrence W. Dobrucki & Albert J. Sinusas Authors * Lawrence W. Dobrucki View author publications You can also search for this

author inPubMed Google Scholar * Albert J. Sinusas View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Albert J.

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Dobrucki, L., Sinusas, A. PET and SPECT in cardiovascular molecular imaging. _Nat Rev Cardiol_ 7, 38–47 (2010). https://doi.org/10.1038/nrcardio.2009.201 Download citation * Published: 24

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