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Access through your institution Buy or subscribe “In patients with sick sinus syndrome (SSS), the occurrence of atrial fibrillation (AF) after pacemaker implantation is very common and
associated with increased risk of stroke, systemic embolism, heart failure, and mortality,” says Hung-Fat Tse from the Queen Mary Hospital in Hong Kong. A study undertaken by Tse and
colleagues, and published in _Circulation_, has shown that neither the use of an alternative atrial pacing site in the right atrial septum, nor continuous atrial overdrive pacing, prevents
the development of persistent AF in patients with SSS. Conventionally, in patients with SSS, pacemakers act at the right atrial appendage; however, whether pacing at other positions in the
atrium provides more-beneficial effects has been unclear. The Septal Pacing for AF Suppression Evaluation (SAFE) study investigators, therefore, compared different rates and sites of pacing
in a single-blind, randomized study of 385 patients with SSS and a history of paroxysmal AF. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access
through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink *
Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional
subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Lau, C.-P., _ et al_. Prospective randomized study to assess the efficacy of site and rate of atrial pacing
on long-term progression of atrial fibrillation in sick sinus syndrome: Septal pacing for atrial fibrillation suppression evaluation (SAFE) study. _Circulation_
doi:10.1161/circulationaha.113.001644 Article Google Scholar Download references Authors * Tim Geach View author publications You can also search for this author inPubMed Google Scholar
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Geach, T. AF pacing in sick sinus syndrome. _Nat Rev Cardiol_ 10, 550 (2013).
https://doi.org/10.1038/nrcardio.2013.119 Download citation * Published: 06 August 2013 * Issue Date: October 2013 * DOI: https://doi.org/10.1038/nrcardio.2013.119 SHARE THIS ARTICLE Anyone
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