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SCREENING MAMMOGRAPHIC SURVEILLANCE IN WOMEN YOUNGER THAN 50 YEARS WHO HAVE A FAMILY HISTORY OF BREAST CANCER: TUMOUR CHARACTERISTICS AND PROJECTED EFFECT ON MORTALITY IN THE PROSPECTIVE,
SINGLE-ARM, FH01 STUDY FH01 collaborative teams. _Lancet Oncol._ 11, 1127–1134 (2010) Women with a family history of breast cancer can be divided into three groups: high risk, medium risk,
and low risk. In the FH01 study, 6,710 medium-risk women (with a family history that indicates their risk is higher than average) under 50 years were enrolled to annual mammography screening
for a mean period of 4 years. This group was compared with a control cohort of women from the 'Age' trial and a Dutch group of women. Predicted 10-year mortality was significantly
lower in the FH01 group than the control groups. Therefore, annual screening is likely to be an effective preventative measure in these medium-risk individuals. DIAGNOSIS FALSE-POSITIVE
RESULTS IN THE RANDOMIZED CONTROLLED TRIAL OF MAMMOGRAPHIC SCREENING FROM AGE 40 (“AGE” TRIAL) Johns, L. E. _ et al_. _Cancer Epidemiol. Biomarkers Prev._ 19, 2758–2764 (2010) A drawback of
breast cancer screening is the high number of false-positive results. Data from the 'Age' trial—that included 53,884 women aged 40 and over—have been used to analyze the frequency
and impact of a false-positive result. The present study revealed a cumulative false-positive rate of 20.5% over seven screens, which was similar to the rate in the national screening
program. This outcome equated to 7,893 women receiving at least one false-positive result. Importantly, 89% of these women attended their next appointment for a routine scan indicating that
the experience of a false-positive result does not deter women from undergoing future routine tests. SCREENING EFFECT OF REPEATED INVITATIONS ON UPTAKE OF COLORECTAL CANCER SCREENING USING
FAECAL OCCULT BLOOD TESTING: ANALYSIS OF PREVALENCE AND INCIDENCE SCREENING Steele, R. J. C. _ et al_. _BMJ_ 341, c5531 (2010) A study has analyzed the uptake of fecal occult blood testing
(FOBT), in Scottish adults aged 50–69 years. For prevalence screening, uptake was 53% for the first invitation, but interestingly 15% and 12% agreed to testing after receiving a second and
third invitation, respectively. The results for incidence screening were more marked with 54% responding positively to the first invitation and a surprising 86% agreeing to screening after
receiving a second invite. These results, and the fact that the positive predictive value of FOBT has been previously shown, indicate that the policy of sending repeat invitations is
correct. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE In brief. _Nat Rev Clin Oncol_ 8, 62 (2011). https://doi.org/10.1038/nrclinonc.2010.215 Download
citation * Published: 31 January 2011 * Issue Date: February 2011 * DOI: https://doi.org/10.1038/nrclinonc.2010.215 SHARE THIS ARTICLE Anyone you share the following link with will be able
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