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Access through your institution Buy or subscribe In a previous _in vitro_ study, Adler and colleagues showed that an N-terminal 24-amino-acid fragment of MARCKS, known as MANS, attenuated
mucin secretion in a concentration-dependent manner, presumably by competitively inhibiting the binding of MARCKS to the membranes of mucin-secreting granules within epithelial cells. Now
the team has shown that intratracheal instillation of MANS blocks mucus hypersecretion in a mouse model of asthma. Mucin secretion at rates fivefold greater than baseline was elicited in
ovalbumin-sensitized mice by administration of aerosolized methacholine. Pretreatment with MANS inhibited this hypersecretory response in a concentration-dependent manner, whereas a missense
N-terminal sequence of MARCKS had no effect. Basal levels of mucin secretion in non-methacholine-exposed mice were also lowered by MANS treatment. This is a preview of subscription content,
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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPER * Singer, M. et al. A MARCKS-related peptide blocks
mucus hypersecretion in a mouse model of asthma. _Nature Med._ 11 January 2004 (doi:10.1038/nm983) FURTHER READING * Li, Y. et al. MARCKS protein is a key molecule regulating mucin secretion
by human airway epithelial cells _in vitro_. _J. Biol. Chem._ 276, 40982–40990 (2001) Article CAS PubMed Google Scholar * Corry, D. B. Emerging immune targets for the therapy of
allergic asthma. _Nature Rev. Drug Discov._ 1, 55–64 (2002) Article CAS Google Scholar Download references Authors * Suzanne Farley View author publications You can also search for this
author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Farley, S. Hitting the MARCKS. _Nat Rev Drug Discov_ 3, 114 (2004).
https://doi.org/10.1038/nrd1317 Download citation * Issue Date: 01 February 2004 * DOI: https://doi.org/10.1038/nrd1317 SHARE THIS ARTICLE Anyone you share the following link with will be
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