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Access through your institution Buy or subscribe Mitochondrial replacement techniques (MRTs) aim to prevent the transmission of mutant mtDNA by creating embryos containing a mother's
unaffected nuclear DNA and non-pathogenic mtDNA from a 'mitochondrial donor'. Human mtDNA exhibits profound within-population sequence variability, but little is known about how
this may affect functional interactions with the nuclear genome. Latorre-Pellicer _et al_. compared metabolic and ageing profiles of wild-type C57BL/6 mice with those of a conplastic mouse
strain, which contains the C57BL/6 nuclear genome and mtDNA from the NZB/OlaHsd mouse strain. That is, the two mouse strains share the same nuclear genome but differ in their mitochondrial
genome. In brief, conplastic mice exhibited less weight gain, slower metabolic decline and fewer signs of ageing over time — including a lower cancer burden at death — than age-matched
wild-type animals. Sequencing of liver mtDNA showed no age-related increase in mtDNA mutations in either mouse strain. This is a preview of subscription content, access via your institution
RELEVANT ARTICLES Open Access articles citing this article. * MITOCHONDRIAL-NUCLEAR EPISTASIS UNDERLYING PHENOTYPIC VARIATION IN BREAST CANCER PATHOLOGY * Pierre R. Bushel * , James Ward *
… Benedict Anchang _Scientific Reports_ Open Access 26 January 2022 ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00
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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Latorre-Pellicer, A. et al.
Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. _Nature_ http://dx.doi.org/10.1038/nature18618 (2016) Download references Authors * Linda Koch View author
publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Koch, L. Nuclear and
mitochondrial genome interplay. _Nat Rev Genet_ 17, 502 (2016). https://doi.org/10.1038/nrg.2016.96 Download citation * Published: 18 July 2016 * Issue Date: September 2016 * DOI:
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