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Access through your institution Buy or subscribe Min-Oo _et al_. identified the pyruvate kinase gene ( _Pklr_ ) as the locus that causes reticulocytosis — an increase in the proportion of
immature red blood cells in the blood — and confers malaria resistance in mice. The discovery that _Pklr_ also underlies resistance to malaria came when the authors tried to find the genetic
basis of malaria resistance in two mouse congenic strains, AcB55 and AcB61. Linkage analysis showed that one locus (dubbed _Char4_ ) that influences parasite load in the blood of these
strains mapped to chromosome 3. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12
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REFERENCES ORIGINAL RESEARCH PAPER * Min-Oo, G. et al. Pyruvate kinase deficiency in mice protects against malaria. _Nature Genet._ 2 November 2003 (doi:10.1038/ng1260) FURTHER READING *
Rogner, U. C. & Avner, P. Congenic mice: cutting tools for complex immune disorders. _Nature Reviews Immunol._ 3, 243–252 (2003) Article CAS Google Scholar Download references Authors
* Magdalena Skipper View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Skipper, M. A simple solution to a complex problem. _Nat Rev Genet_ 4, 929 (2003). https://doi.org/10.1038/nrg1232 Download citation * Issue Date: 01 December 2003 * DOI:
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