Play all audios:
Access through your institution Buy or subscribe Peter Becker's group investigated how the MSL complex identifies and binds the X chromosome in fly embryos using high-resolution genomic
tiling arrays. They found that just over half the annotated genes on the X chromosome were bound by the complex. Preferred targets were essential genes, and the greatest compensation was
seen for genes that bound high levels of the MSL complex. Notably, genes, rather than intergenic regions, were favoured by the complex, which bound most strongly to the 3′ end of the
transcription units. The authors proposed a model in which individual genes that are under selective pressure to equalize dosage between the sexes have evolved targeting signals to attract
the MSL complex. Peter Park, Mitzi Kuroda and colleagues also determined the X-chromosome-specific binding pattern of the MSL complex in two male cell lines and in embryos, again using
high-resolution genomic tiling arrays. Similarly to Becker's group, the authors found that the MSL complex recognizes and preferentially binds to genes rather than intergenic regions;
the binding is also biased towards the 3′ end of the transcription units. The same gene sequences can be clearly bound or unbound by the MSL complex, depending on cell type, indicating that
MSL targeting cannot be explained by sequence alone. The authors proposed that the MSL complex selectively targets most X-linked genes, but only within the context of active transcription.
This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access
$209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are
calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPER *
Gilfillan, G. D. et al. Chromosome-wide gene-specific targeting of the _Drosophila_ dosage compensation complex. _Genes Dev._ 17 March 2006 (doi:10.1101/gad.1399406) * Alekseyenko, A. A. et
al. High-resolution ChIP–chip analysis reveals that the _Drosophila_ MSL complex selectively identifies active genes on the male X chromosome. _Genes Dev._ 17 March 2006
(doi:10.1101/gad.100206) * Legube, G. et al. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in _Drosophila_. _Genes Dev._ 17 March 2006 (doi:10.1101/gad.377506)
FURTHER READING * Schübeler, D. Dosage compensation in high resolution: global up-regulation through local recruitment. _Genes Dev._ 17 March 2006 (doi:10.1101/gad.1423006) Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Assistant Editor, Nature Reviews Molecular Cell Biology, Sharon Ahmad Authors * Sharon Ahmad View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ahmad, S. Compensation Culture. _Nat Rev Genet_ 7, 335
(2006). https://doi.org/10.1038/nrg1867 Download citation * Issue Date: 01 May 2006 * DOI: https://doi.org/10.1038/nrg1867 SHARE THIS ARTICLE Anyone you share the following link with will be
able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing
initiative