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Access through your institution Buy or subscribe > both commensal bacteria and self-antigen recognition are required > for the initiation of autoimmune responses The intestinal
microbiota actively regulates local immune responses, partly through the induction of interleukin-17 (IL-17)-producing T cells and regulatory T cells, but its contribution to immune
responses at distal sites is largely unknown. Relapsing–remitting EAE develops spontaneously in transgenic mice of the SJL/J background in which a proportion of CD4+ T cells are engineered
to express a T cell receptor that is specific for the self antigen myelin oligodendrocyte glycoprotein (MOG). As disease incidence in these transgenic mice varies among different animal
facilities, the authors asked whether the composition of the intestinal microbiota might have a role in EAE development. This is a preview of subscription content, access via your
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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in
* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPER * Berer, K. et al. Commensal microbiota and myelin autoantigen
cooperate to trigger autoimmune demyelination. _Nature_ 26 Oct 2011 (doi:10.1038/nature10554) FURTHER READING * Gill, N. & Finlay, B. B. The gut microbiota: challenging immunology.
_Nature Rev. Immunol._ 11, 636–637 (2011) Article CAS Google Scholar Download references Authors * Maria Papatriantafyllou View author publications You can also search for this author
inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Papatriantafyllou, M. Linking commensals with autoimmunity. _Nat Rev Immunol_ 11,
803 (2011). https://doi.org/10.1038/nri3114 Download citation * Published: 11 November 2011 * Issue Date: December 2011 * DOI: https://doi.org/10.1038/nri3114 SHARE THIS ARTICLE Anyone you
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