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Access through your institution Buy or subscribe > memory CD8+ T cells possess greater mitochondrial spare respiratory > capacity Conversion between different metabolic states has been
linked with the acquisition of distinct T cell functions, so the authors measured the bioenergetic profiles of naive, effector and memory CD8+ T cells in mice infected with _Listeria
monocytogenes_. In keeping with previous findings that activated T cells switch from oxidative phosphorylation to glycolytic respiration, effector CD8+ T cells showed higher basal rates of
glycolysis compared with other CD8+ T cells. Memory CD8+ T cells had slightly higher basal rates of oxidative phosphorylation but, interestingly, demonstrated a markedly enhanced SRC. This
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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPER * Van der Windt,
G. J. W. et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. _Immunity_ 29 Dec 2011 (doi: 10.1016/j.immuni.2011.12.007)Article Article
Google Scholar FURTHER READING * Finlay, D. & Cantrell, D. A. Metabolism, migration and memory in cytotoxic T cells. _Nature Rev. Immunol._ 11, 109–117 (2011) Article CAS Google
Scholar Download references Authors * Yvonne Bordon View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE Bordon, Y. IL-15 provides breathing space for memory. _Nat Rev Immunol_ 12, 77 (2012). https://doi.org/10.1038/nri3162 Download citation * Published: 25
January 2012 * Issue Date: February 2012 * DOI: https://doi.org/10.1038/nri3162 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable
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