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Access through your institution Buy or subscribe Early endosomes are morphologically and functionally heterogeneous, and include APPL, WDFY2 and classical EEA1 endosomes. Zoncu _et al_. now
show that APPL endosomes, which are characterized by the adaptor proteins APPL1 and APPL2, are precursors of classical early endosomes. Fluorescently tagged APPL1 transiently associates with
macropinosomes and is then lost from their membranes as these acquire phosphatidylinositol-3-phosphate (PtdIns3P). APPL endosomes are also generated from clathrin-coated pits near the cell
edge. A significant fraction of APPL endosomes are precursors of WDFY2 and EEA1 endosomes. WDFY2 endosomes, in turn, gradually acquire EEA1 and converge into EEA1 endosomes. This is a
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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Zoncu, R. et al. A
phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. _Cell_ 136, 1110–1121 (2009) Article CAS PubMed PubMed Central Google Scholar Download
references Authors * Arianne Heinrichs View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE
CITE THIS ARTICLE Heinrichs, A. Earliest endosomes. _Nat Rev Mol Cell Biol_ 10, 302 (2009). https://doi.org/10.1038/nrm2676 Download citation * Published: 02 April 2009 * Issue Date: May
2009 * DOI: https://doi.org/10.1038/nrm2676 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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