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Access through your institution Buy or subscribe In 2005, Duojia Pan's laboratory at Johns Hopkins University, Maryland, USA, reported a major discovery: they had identified Yorkie, the
_Drosophila melanogaster_ homologue of YAP and TAZ, as the key effector of the Hippo signalling pathway. Until this point, the Hippo pathway was known to consist of a series of tumour
suppressor proteins, including the upstream Hippo kinase and downstream Warts kinase (LATS1 and LATS2 are homologues in mammals), but the mechanism by which they controlled growth was a
mystery. The identification of Yorkie as the missing link between Warts and the control of transcription revolutionized the field of Hippo signalling and is proving to have a profound impact
on cancer research. > The name Yorkie was chosen because the small size phenotype of the > _D. melanogaster yorkie_-mutant tissues was reminiscent of Yorkshire > Terriers This is a
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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Huang, J. et al. The Hippo signaling
pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the _Drosophila_ homolog of YAP. _Cell_ 122, 421–434 (2005) Article CAS Google Scholar Download
references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * The Francis Crick Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK Barry J. Thompson Authors * Barry J. Thompson View
author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Barry J. Thompson. ETHICS DECLARATIONS COMPETING INTERESTS The author
declares no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Thompson, B. From hippos to yorkies in one pathway. _Nat Rev
Mol Cell Biol_ 16, 392 (2015). https://doi.org/10.1038/nrm4011 Download citation * Published: 17 June 2015 * Issue Date: July 2015 * DOI: https://doi.org/10.1038/nrm4011 SHARE THIS ARTICLE
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