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Access through your institution Buy or subscribe Childhood diarrhoea is associated with infection of the gut by pathogens such as _Vibrio cholerae_ and enterotoxigenic _Escherichia coli_
(ETEC), but how the gut microbiota recovers post infection is incompletely understood. David _et al_. analysed the microbiome of rectal samples from 13 patients with cholera and 18 patients
with ETEC at early, mid and late stages during recovery. Recovery to a normal microbiome occurred only at the late stage, 30 days after infection, but distinct groups of bacteria were
reproducibly present at the early and mid stages. Taxonomic and functional data supported a succession model in which infection-induced diarrhoea depletes the gut microbiota, resulting in
elevated oxygen and carbohydrate levels in the gut; facultative anaerobes that reach the gut by food ingestion or by migration then colonize the gut; aerobic respiration by these bacteria
lowers the oxygen levels in the gut; as oxygen levels fall, obligate anaerobes recolonize the gut and alter the carbohydrate composition to favour 'healthy' commensals and promote
recovery. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online
access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which
are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * David, L. A. et al. Gut
microbial succession follows acute secretory diarrhea in humans. _mBio_ 6, e00381-15 (2015) Article Google Scholar Download references Authors * Naomi Attar View author publications You
can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Attar, N. A gut instinct for recovery. _Nat Rev
Microbiol_ 13, 398 (2015). https://doi.org/10.1038/nrmicro3513 Download citation * Published: 08 June 2015 * Issue Date: July 2015 * DOI: https://doi.org/10.1038/nrmicro3513 SHARE THIS
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