Waves of fear | Nature Reviews Neuroscience

Waves of fear | Nature Reviews Neuroscience

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Access through your institution Buy or subscribe Long-range synchronization of neural activity is thought to contribute to fear behaviour. Karalis _et al_. show in mice that sustained synchronized 4 Hz oscillations in the dorsal medial prefrontal cortex (dmPFC) and the basolateral amygdala (BLA) predict internally generated freezing behaviour (in the absence of a cue) and cue-induced freezing behaviour following fear conditioning training, but they do not predict periods of passive immobility that occur prior to fear conditioning. Individual neurons in the dmPFC and BLA synchronized their firing to 4 Hz oscillations during freezing behaviour following fear conditioning, and optogenetically driving dmPFC neuronal activity at 4 Hz increased the number of freezing bouts. 4 Hz oscillations in the prefrontal–amygdala circuit may therefore be involved in the initiation and maintenance of fear behaviour. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Karalis, N. et al. 4-Hz oscillations synchronize prefrontal–amygdala circuits during fear behavior. _Nat. Neurosci._ http://dx.doi.org/10.1038/nn.4251 (2016) Download references Authors * Fiona Carr View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Carr, F. Waves of fear. _Nat Rev Neurosci_ 17, 200 (2016). https://doi.org/10.1038/nrn.2016.32 Download citation * Published: 10 March 2016 * Issue Date: April 2016 * DOI: https://doi.org/10.1038/nrn.2016.32 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

Access through your institution Buy or subscribe Long-range synchronization of neural activity is thought to contribute to fear behaviour. Karalis _et al_. show in mice that sustained


synchronized 4 Hz oscillations in the dorsal medial prefrontal cortex (dmPFC) and the basolateral amygdala (BLA) predict internally generated freezing behaviour (in the absence of a cue) and


cue-induced freezing behaviour following fear conditioning training, but they do not predict periods of passive immobility that occur prior to fear conditioning. Individual neurons in the


dmPFC and BLA synchronized their firing to 4 Hz oscillations during freezing behaviour following fear conditioning, and optogenetically driving dmPFC neuronal activity at 4 Hz increased the


number of freezing bouts. 4 Hz oscillations in the prefrontal–amygdala circuit may therefore be involved in the initiation and maintenance of fear behaviour. This is a preview of


subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $189.00 per year only


$15.75 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout


ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Karalis, N. et al. 4-Hz oscillations synchronize


prefrontal–amygdala circuits during fear behavior. _Nat. Neurosci._ http://dx.doi.org/10.1038/nn.4251 (2016) Download references Authors * Fiona Carr View author publications You can also


search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Carr, F. Waves of fear. _Nat Rev Neurosci_ 17, 200 (2016).


https://doi.org/10.1038/nrn.2016.32 Download citation * Published: 10 March 2016 * Issue Date: April 2016 * DOI: https://doi.org/10.1038/nrn.2016.32 SHARE THIS ARTICLE Anyone you share the


following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer


Nature SharedIt content-sharing initiative