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Access through your institution Buy or subscribe Long-range synchronization of neural activity is thought to contribute to fear behaviour. Karalis _et al_. show in mice that sustained
synchronized 4 Hz oscillations in the dorsal medial prefrontal cortex (dmPFC) and the basolateral amygdala (BLA) predict internally generated freezing behaviour (in the absence of a cue) and
cue-induced freezing behaviour following fear conditioning training, but they do not predict periods of passive immobility that occur prior to fear conditioning. Individual neurons in the
dmPFC and BLA synchronized their firing to 4 Hz oscillations during freezing behaviour following fear conditioning, and optogenetically driving dmPFC neuronal activity at 4 Hz increased the
number of freezing bouts. 4 Hz oscillations in the prefrontal–amygdala circuit may therefore be involved in the initiation and maintenance of fear behaviour. This is a preview of
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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Karalis, N. et al. 4-Hz oscillations synchronize
prefrontal–amygdala circuits during fear behavior. _Nat. Neurosci._ http://dx.doi.org/10.1038/nn.4251 (2016) Download references Authors * Fiona Carr View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Carr, F. Waves of fear. _Nat Rev Neurosci_ 17, 200 (2016).
https://doi.org/10.1038/nrn.2016.32 Download citation * Published: 10 March 2016 * Issue Date: April 2016 * DOI: https://doi.org/10.1038/nrn.2016.32 SHARE THIS ARTICLE Anyone you share the
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