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Access through your institution Buy or subscribe RNA-binding proteins (RBPs) are implicated in several neurodegenerative diseases. However, it is unclear whether they influence the
pathophysiology of neurodegenerative disorders associated with tau pathology (so-called tauopathies), such as Alzheimer disease (AD). Now, Apicco _et al_. show that reducing the level of the
RBP T cell intracellular antigen 1 (TIA1) protects against tau-induced neuronal death, cognitive dysfunction and premature death in mice. Here, the authors examined whether altering TIA1
levels could influence tau-mediated pathophysiology _in vivo_. They crossed _Tia1_−/− mice with PS19 mice, which express a pathological form of human tau (P301S tau), and then crossed
selected offspring to generate mice harbouring the P301S tau transgene and either one or both copies of _Tia1_ (P301S _Tia1_−/+ mice and P301S _Tia1_+/+ mice, respectively). As expected,
P301S _Tia1_−/+ mice expressed ∼50% lower levels of TIA1 than P301S _Tia1_+/+ mice. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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REFERENCES * Apicco, D. J. et al. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration _in vivo_. _Nat. Neurosci._
http://dx.doi.org/10.1038/s41593-017-0022-z (2017) Download references Authors * Darran Yates View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Yates, D. Tackling tauopathy. _Nat Rev Neurosci_ 19, 1 (2018). https://doi.org/10.1038/nrn.2017.163 Download
citation * Published: 14 December 2017 * Issue Date: January 2018 * DOI: https://doi.org/10.1038/nrn.2017.163 SHARE THIS ARTICLE Anyone you share the following link with will be able to read
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