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Access through your institution Buy or subscribe > these data indicate that, in mice, consumption of high levels of > salt leads to changes in resting CBF that precede or coincide with
> the development of cognitive deficits The authors fed mice a diet containing an 8-fold to 16-fold higher level of salt than was present in the normal mouse diet. After 12 weeks of
consuming this HSD, the mice performed poorly in the novel object recognition task, the Barnes maze and nesting behaviour, reflecting impairments in nonspatial memory, spatial memory and
limbic function, respectively. Changes in resting cerebral blood flow (CBF) can impair cognitive function and, here, consumption of the HSD for 8 and 12 weeks was associated with respective
reductions in resting CBF in the cortex and the hippocampus. Together, these data indicate that, in mice, consumption of high levels of salt leads to changes in resting CBF that precede or
coincide with the development of cognitive deficits. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and
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which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Faraco, G. et al.
Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. _Nat. Neurosci._ 21, 240–249 (2018) Article CAS PubMed PubMed Central Google Scholar
Download references Authors * Darran Yates View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Yates, D. Dietary salt-induced deficits. _Nat Rev Neurosci_ 19, 122 (2018). https://doi.org/10.1038/nrn.2018.15 Download citation * Published: 16 February 2018 *
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