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Access through your institution Buy or subscribe The presence of RA-synthesizing enzymes, such as retinaldehyde dehydrogenase-2 (RALDH2), is a reliable indicator of a source of RA. Zhang _et
al_. showed that the _Raldh2_ gene is expressed in the meninges — a layer of tissue of mesenchymal origin that surrounds the brain — from around embryonic day 13 in the hindbrain region.
The authors confirmed that the meninges can secrete RA by showing that isolated meningeal tissue could release RA into a tissue culture medium. To find out where RA signalling was taking
place, the authors examined transgenic mouse embryos in which a RA response element controlled the expression of a _lacZ_ reporter gene. They showed that _lacZ_ was expressed in cells that
migrated beneath the meninges to colonize precerebellar nuclei. They also found that the RA catabolic enzyme CYP26B1 was expressed in the deeper layers of the hindbrain, perhaps indicating
that other hindbrain tissues need to be protected from the effects of RA. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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our FAQs * Contact customer support REFERENCES ORIGINAL RESEARCH PAPER * Zhang, J. et al. The meninges is a source of retinoic acid for the late-developing hindbrain. _J. Neurosci._ 23,
7610–7620 (2003) Article CAS Google Scholar FURTHER READING * Maden, M. Retinoid signalling in the development of the central nervous system. _Nature Rev. Neurosci._ 3, 843–853 (2002)
Article CAS Google Scholar Download references Authors * Heather Wood View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints
and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Wood, H. A new source of RA. _Nat Rev Neurosci_ 4, 774 (2003). https://doi.org/10.1038/nrn1228 Download citation * Issue Date: 01 October
2003 * DOI: https://doi.org/10.1038/nrn1228 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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