Access through your institution Buy or subscribe Integrins are adhesion molecules that are expressed on primary afferent neurons. They bind to elements of the extracellular matrix (ECM) and

interact with signalling systems that are known to mediate hyperalgesia. Inflammation and nerve injury cause changes in the ECM around peripheral nerves that might provide important signals

to integrins. So, the authors investigated whether integrins were involved in the sensitization of nociceptors that leads to hyperalgesia in animal models of inflammatory and neuropathic

pain. Dina _et al_. used several methods to interfere with normal integrin signalling in rats, and found that by doing so they could block the development of hyperalgesia. However, there

to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read

our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Dina, O. A. et al. Integrin signaling in inflammatory and neuropathic pain in the rat. _Eur. J. Neurosci._ 19, 634–642 (2004)

Article  Google Scholar  Download references Authors * Rachel Jones View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jones, R. The pain of integrins. _Nat Rev Neurosci_ 5, 169 (2004). https://doi.org/10.1038/nrn1359 Download citation * Issue Date: 01 March

2004 * DOI: https://doi.org/10.1038/nrn1359 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not

currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative