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Access through your institution Buy or subscribe DOC2B IS A HIGH-AFFINITY CA2+ SENSOR FOR SPONTANEOUS NEUROTRANSMITTER RELEASE Groffen, A. J. _et al_. _Science_ 11 Feb 2010 (doi:
10.1126/science.1183765) Double C2 domain protein B (DOC2B) enhances exocytosis in chromaffin cells, pancreatic β-cells and adipocytes. Here, the authors showed that it also mediates
spontaneous vesicle release from mouse hippocampal and cerebellar neurons. DOC2B is structurally and biochemically similar to synaptotagmin 1, which also contains two cytoplasmic C2 domains,
and competes with synaptotagmin 1 for SNARE (soluble _N_-ethylmaleimide-sensitive factor attachment receptor) complex binding. These findings highlight the membrane curvature-inducing
action of multiple C2 domain proteins in neurotransmitter release. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution
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Contact customer support RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE In Brief. _Nat Rev Neurosci_ 11, 225 (2010). https://doi.org/10.1038/nrn2830
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