Play all audios:
Access through your institution Buy or subscribe Synaptic plasticity requires AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor) trafficking, and the authors showed that
leptin increased the surface expression of GluR1 AMPAR subunits in hippocampal slices. Leptin did not have this effect in the presence of exocytosis inhibitors or in slices from obese Zucker
rats, which are leptin-insensitive owing to a mutation in the leptin receptor gene. These findings indicate that leptin-induced GluR1 surface expression is due to enhanced GluR1 exocytosis
and requires leptin receptor activation. The effect on GluR1 expression had functional consequences: leptin enhanced the amplitude of excitatory postsynaptic currents (EPSCs) in hippocampal
slices from wild-type and lean Zucker rats but not in slices from obese Zucker rats. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
institution Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Learn more Buy this article * Purchase on SpringerLink * Instant
access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions *
Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Moult, P. R. et al. Leptin regulates AMPA receptor trafficking via PTEN inhibition. _J. Neurosci._ 30, 4088–4101 (2010)
Article CAS PubMed PubMed Central Google Scholar Download references Authors * Leonie Welberg View author publications You can also search for this author inPubMed Google Scholar RIGHTS
AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Welberg, L. An appetite for learning. _Nat Rev Neurosci_ 11, 298 (2010). https://doi.org/10.1038/nrn2844
Download citation * Published: 14 April 2010 * Issue Date: May 2010 * DOI: https://doi.org/10.1038/nrn2844 SHARE THIS ARTICLE Anyone you share the following link with will be able to read
this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative