ABSTRACT The circadian clock machinery is responsible for biological timekeeping on a systemic level. The central clock system controls peripheral clocks through a number of output cues that

synchronize the system as a whole. There is growing evidence that changing cellular metabolic states have important effects on circadian rhythms and can thereby influence neuronal function

and disease. Epigenetic control has also been implicated in the modulation of biological timekeeping, and cellular metabolism and epigenetic state seem to be closely linked. We discuss the

idea that cellular metabolic state and epigenetic mechanisms might work through the circadian clock to regulate neuronal function and influence disease states. Access through your

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BEING VIEWED BY OTHERS THE METABOLIC SIGNIFICANCE OF PERIPHERAL TISSUE CLOCKS Article Open access 26 March 2025 MOLECULAR REGULATIONS OF CIRCADIAN RHYTHM AND IMPLICATIONS FOR PHYSIOLOGY AND

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influences the circadian clock. _Science_ 333, 1881–1885 (2011). Article  CAS  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS We thank all members of the

Sassone-Corsi laboratory for helpful discussion. Funding for S.M. was provided by the US National Institutes of Health (NIH) postdoctoral fellowship GM097899. Financial support for P.S.-C

was provided bythe US NIH (grant AG041504), INSERM (grant 44790) and Sirtris Pharmaceuticals (SP-48984). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Selma Masri and Paolo Sassone-Corsi are

at the Department of Biological Chemistry, Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, California 92697, USA., Selma Masri & Paolo

Sassone-Corsi Authors * Selma Masri View author publications You can also search for this author inPubMed Google Scholar * Paolo Sassone-Corsi View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Paolo Sassone-Corsi. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial

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Masri, S., Sassone-Corsi, P. The circadian clock: a framework linking metabolism, epigenetics and neuronal function. _Nat Rev Neurosci_ 14, 69–75 (2013). https://doi.org/10.1038/nrn3393

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