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Access through your institution Buy or subscribe Nitric oxide synthase 1 (NOS1) has roles in different forms of plasticity. A NOS1 isoform, NOS1α, also plays a part in stroke by contributing
to ischaemic damage. As this pathophysioloigcal effect is greater in males than in females, the authors tested whether the role of NOS1α in plasticity is also sex-specific. Male NOS1α-null
mice showed no long-term potentiation (LTP) between barrel columns and reduced experienced-dependent potentiation (EDP) in the barrel cortex. By contrast, LTP and EDP in the barrel cortex
could be detected in NOS1α-null female mice, indicating that neocortical plasticity mechanisms may show sex-specific differences. This is a preview of subscription content, access via your
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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in
* Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Dachtler, J., Hardingham, N. R. & Fox, K. The role of nitric oxide synthase
in cortical plasticity is sex specific. _J. Neurosci._ 32, 14994–14999 (2012) Article CAS Google Scholar Download references Authors * Darran Yates View author publications You can also
search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Yates, D. Plasticity gets sex-specific. _Nat Rev Neurosci_
13, 817 (2012). https://doi.org/10.1038/nrn3401 Download citation * Published: 20 November 2012 * Issue Date: December 2012 * DOI: https://doi.org/10.1038/nrn3401 SHARE THIS ARTICLE Anyone
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