Access through your institution Buy or subscribe Glucocorticoids are released in response to stress, and activation of the glucocorticoid receptor usually feeds back to reduce glucocorticoid

release. FKBP5 forms part of a negative-feedback loop that regulates glucocorticoid receptor activity, so changes in levels of FKBP5 could perturb the stress response system and leave

people vulnerable to conditions such as PTSD. The authors identified a polymorphism in intron 2 of _FKBP5_. Adults who were homozygous or heterozygous for the A (risk) allele at this

polymorphism rather than the G (protective) allele were more likely to suffer from PTSD — but only if they had suffered abuse as children. This is a preview of subscription content, access

Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Klengel, T. et al. Allele-specific _FKBP5_ DNA demethylation mediates

gene–childhood trauma interactions. _Nature Neurosci._ 2 Dec 2012 (doi:10.1038/nn.3275) Article  Google Scholar  Download references Authors * Rachel Jones View author publications You can

also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jones, R. Trauma and stress, from child to adult.

_Nat Rev Neurosci_ 14, 77 (2013). https://doi.org/10.1038/nrn3425 Download citation * Published: 19 December 2012 * Issue Date: February 2013 * DOI: https://doi.org/10.1038/nrn3425 SHARE

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