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The differential expression of chemoreceptors in mature left ASE (ASEL) and right ASE (ASER) neurons defines their functional asymmetry, and the transcription factors die-1 and cog-1, as
well as the miRNA lsy-6, have been implicated in the maintenance of this asymmetric gene expression pattern. The authors show that lsy-6 is the first gene to be asymmetrically expressed in
ASE neurons, as high levels were detected at the end of gastrulation in the mother cell of the ASEL neuron but not in that of the ASER neuron. Further analysis revealed that two
cis-regulatory elements are necessary for the exclusive expression of lsy-6 in ASEL. Whereas the cis-regulatory element found upstream of the lsy-6 hairpin is regulated by the zinc finger
transcription factor CHE-1, which is present in both mature ASE neurons, a downstream cis-regulatory element responds to two T-box transcription factors, TBX-37 and TBX-38, which are only
present early and transiently in the lineage that gives rise to ASEL (ABa) but not ASER (ABp).
microRNA (miRNA) priming is a key event in the early embryonic stages for establishing ... functional asymmetry ...
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