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Access through your institution Buy or subscribe G protein-coupled oestrogen receptor 1 (GPER1) is expressed in hippocampal dendritic spines and axon terminals, but its role in long-term
depression (LTD) is not known. Here, 17β-estradiol (E2) activation of GPER1 in CA3 resulted in the release of brain-derived neurotrophic factor and the local translation of
activity-regulated cytoskeleton-associated protein (ARC). This increase in ARC levels led to the internalization and proteasome-mediated degradation of GluA1-containing AMPA receptors, and
LTD, thus revealing a novel way in which E2 can mediate synaptic plasticity in the hippocampus. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access
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Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional
subscriptions * Read our FAQs * Contact customer support REFERENCES * Briz, V. et al. A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF
release. _J. Cell Biol._ 210, 1225–1237 (2015) Article CAS PubMed PubMed Central Google Scholar Download references Authors * Sian Lewis View author publications You can also search for
this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Lewis, S. Neurotrophic memory. _Nat Rev Neurosci_ 16, 646 (2015).
https://doi.org/10.1038/nrn4049 Download citation * Published: 20 October 2015 * Issue Date: November 2015 * DOI: https://doi.org/10.1038/nrn4049 SHARE THIS ARTICLE Anyone you share the
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