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Access through your institution Buy or subscribe The authors developed a mouse model of accelerated tau propagation: they injected an adeno-associated virus (AAV) that expressed a mutant
form of human tau (h-tau) under the control of a neuron-specific promoter into the medial EC of 4-month-old mice (AAV-h-tau mice). Using immunohistochemistry, the authors found that
hyperphosphorylated human tau (ph-tau) accumulated in the terminals of EC axons in the outer molecular layer of the DG around 7 days after injection, and in the DG granule cell layer at 28
days post-injection. This propagation occurred more rapidly than in previously studied transgenic models expressing mutant h-tau. The oligomeric form of tau was also detected in the DG
granule cell layer, at both time points. Some of the accumulated h-tau in the DG was co-localized with microglial markers, suggesting that microglia had phagocytosed h-tau. _In vitro_
experiments confirmed that mouse microglia could phagocytose a pre-aggregated form of h-tau, and electron microscopy of the hippocampus in the PS19 mouse model of AD (in which mice
ubiquitously express the same h-tau mutant in neurons) also revealed evidence of microglial phagocytosis of h-tau aggregates. This is a preview of subscription content, access via your
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article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in
* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Asai, H. et al. Depletion of microglia and inhibition of exosome synthesis halt tau
propagation. _Nat. Neurosci._ http://dx.doi.org/10.1038/nn.4132 (2015) Download references Authors * Fiona Carr View author publications You can also search for this author inPubMed Google
Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Carr, F. Tau distributors. _Nat Rev Neurosci_ 16, 702–703 (2015). https://doi.org/10.1038/nrn4056
Download citation * Published: 28 October 2015 * Issue Date: December 2015 * DOI: https://doi.org/10.1038/nrn4056 SHARE THIS ARTICLE Anyone you share the following link with will be able to
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