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Access through your institution Buy or subscribe A study published in the _Journal of Clinical Investigation_ reports on a protein network that has a key role in generating and maintaining
the glomerular filtration barrier (GFB) in the kidney. First, the researchers—in collaboration with Pietro De Camilli—showed that podocyte-selective knockout of the dynamin 1 and dynamin 2
genes in mice led to effacement of foot processes, severe proteinuria and kidney failure. Next, they demonstrated that knockout mice lacking either synaptojanin 1 or the three endophilin
proteins (which are all key functional partners of dynamin at neuronal synapses) were macroscopically normal at birth but had impaired neurological function and an underdeveloped GFB that
resulted in severe proteinuria. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12
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RESEARCH PAPER * Soda, K. _ et al_. Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. _J. Clin. Invest._ doi:10.1172/JCI65289 Download references Authors * Rebecca
Kelsey View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kelsey, R.
Protein network involved in maintaining kidney permeability. _Nat Rev Nephrol_ 9, 64 (2013). https://doi.org/10.1038/nrneph.2012.271 Download citation * Published: 11 December 2012 * Issue
Date: February 2013 * DOI: https://doi.org/10.1038/nrneph.2012.271 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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