Observational studies suggest that high homocysteine levels are a risk factor for brain atrophy and Alzheimer disease, but intervention studies have been inconclusive. New evidence that B

vitamin therapy can slow brain atrophy will allow re-examination of elevated homocysteine levels as a potentially treatable risk factor for this disease. Access through your institution Buy

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Article  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Brain and Ageing Research Program, School of Psychiatry, University of New South

Wales, Neuropsychiatric Institute, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Sydney, Australia Perminder S. Sachdev Authors * Perminder S. Sachdev View

author publications You can also search for this author inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing financial interests. RIGHTS AND

PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sachdev, P. Homocysteine and Alzheimer disease: an intervention study. _Nat Rev Neurol_ 7, 9–10 (2011).

https://doi.org/10.1038/nrneurol.2010.195 Download citation * Published: 10 January 2011 * Issue Date: January 2011 * DOI: https://doi.org/10.1038/nrneurol.2010.195 SHARE THIS ARTICLE Anyone

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