Play all audios:
Access through your institution Buy or subscribe “Previous studies, including our own, reported that blocking of Drp1 function was sufficient to attenuate mitochondrial dysfunction and
neurotoxicity in PD cell culture models,” explains Tieu. “However, the _in vivo_ significance of this finding needed to be evaluated in animal models of PD.” Tieu's team used two
complementary mouse models that recapitulated different aspects of PD: a _PINK1_ gene deletion model that showed defects in evoked striatal dopamine release, and an MPTP neurotoxic model
that exhibited dopaminergic neurodegeneration. Drp1 blockade was accomplished by a small-molecule inhibitor or by expression of a dominant-negative form of the protein. This is a preview of
subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only
$17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout
ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Rappold, P. M. _ et al_. Drp1 inhibition attenuates
neurotoxicity and dopamine release defects _in vivo_. _Nat. Commun._ 5, 5244 (2014) Article CAS Google Scholar Download references Authors * Heather Wood View author publications You can
also search for this author inPubMed Google Scholar RELATED LINKS RELATED LINKS RELATED LINKS IN NATURE RESEARCH Cui, M. _ et al_. Perturbations in mitochondrial dynamics induced by human
mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. _J. Biol. Chem._ 285, 11740–11752 (2010) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE
THIS ARTICLE Wood, H. Blocking mitochondrial fission—a new treatment approach for Parkinson disease?. _Nat Rev Neurol_ 11, 2 (2015). https://doi.org/10.1038/nrneurol.2014.227 Download
citation * Published: 25 November 2014 * Issue Date: January 2015 * DOI: https://doi.org/10.1038/nrneurol.2014.227 SHARE THIS ARTICLE Anyone you share the following link with will be able to
read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing
initiative