Targeting tauopathies for therapeutic translation

Targeting tauopathies for therapeutic translation

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Tau protein abnormalities are key pathogenic features of Alzheimer disease and other neurodegenerative diseases. In 2015, new studies of the less common tauopathies, including progressive


supranuclear palsy, chronic traumatic encephalopathy and frontotemporal lobar degeneration, have identified _in vivo_ biomarkers and mechanisms that initiate tau pathology. Access through


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http://dx.doi.org/10.1002/ana.24546 (2015). Download references ACKNOWLEDGEMENTS J.C.R. and A.L.B. are supported by NIH (grants U54NS092089 and R01AG038791) and the Tau Consortium. AUTHOR


INFORMATION AUTHORS AND AFFILIATIONS * Department of Neurology, Clinical Trials Program, Memory and Aging Center, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190,


MC 1207, San Francisco, 94143, California, USA Julio C. Rojas & Adam L. Boxer Authors * Julio C. Rojas View author publications You can also search for this author inPubMed Google


Scholar * Adam L. Boxer View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Adam L. Boxer. ETHICS DECLARATIONS


COMPETING INTERESTS A.L.B. has received research support from Avid, Biogen, Bristol Myers Squibb, C2N Diagnostics, Cortice Biosciences, Eli Lilly, Forum Pharmaceuticals, Genentech and TauRx.


He has served as a consultant for Asceneuron, Ipierian, Ionis (formerly Isis) Pharmaceuticals, Janssen and Merck. He serves on a Data and Safety Monitoring Board for Neurogenetics


Pharmaceuticals. He has stock and/or options in Alector and Delos. J.C.R. declares no competing interests. RELATED LINKS WEB LINKS The Genetic FTD Initiative (GENFI) Advancing Research and


Treatment for Frontotemporal Lobar Degeneration (ARTFL) POWERPOINT SLIDES POWERPOINT SLIDE FOR FIG. 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE


Rojas, J., Boxer, A. Targeting tauopathies for therapeutic translation. _Nat Rev Neurol_ 12, 74–76 (2016). https://doi.org/10.1038/nrneurol.2016.5 Download citation * Published: 22 January


2016 * Issue Date: February 2016 * DOI: https://doi.org/10.1038/nrneurol.2016.5 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable


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