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Access through your institution Buy or subscribe Ponticos, M. _ et al_. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I
collagen. _Arthritis Rheum._ 60, 2142–2155 (2009). New research suggests that connective tissue growth factor (CTGF, also known as CCN2) is an essential component in the development of
pulmonary fibrosis, a common clinical manifestation of systemic sclerosis. CTGF is a member of the matricellular class of proteins, and is involved in cell–matrix interactions during wound
healing and connective tissue repair. Observations of elevated CTGF expression in the fibrotic lesions of patients with connective tissue diseases, however, suggest that the protein could
also be a direct profibrotic mediator. “CTGF has previously been implicated in the promotion of liver fibrosis and diabetic nephropathy,” explains Andrew Leask, an investigator on the new
study. “We wanted to see if CTGF is also important for lung fibrosis.” This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution
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Contact customer support Authors * Negin Nassabeh View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT
THIS ARTICLE CITE THIS ARTICLE Nassabeh, N. Elucidating the origins of lung fibrosis. _Nat Rev Rheumatol_ 5, 467 (2009). https://doi.org/10.1038/nrrheum.2009.153 Download citation * Issue
Date: September 2009 * DOI: https://doi.org/10.1038/nrrheum.2009.153 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry,
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