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Medications that inhibit gastric acid secretion are standard co-therapy with NSAIDs, but evidence is emerging of a link between prolonged use of these agents and an increased risk of hip
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support REFERENCES * Wolfe, M. M., Lichtenstein, D. R. & Singh, G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. _N. Engl. J. Med._ 340, 1888–1899 (1999). Article
CAS PubMed Google Scholar * Lanas, A. & Hunt, R. Prevention of anti-inflammatory drug-induced gastrointestinal damage: benefits and risks of therapeutic strategies. _Ann. Med._ 38,
415–428 (2006). Article CAS PubMed Google Scholar * Yang, Y. X., Lewis, J. D., Epstein, S. & Metz, D. C. Long-term proton pump inhibitor therapy and risk of hip fracture. _JAMA_ 296,
2947–2953 (2006). Article CAS PubMed Google Scholar * Vestergaard, P., Rejnmark, L. & Mosekilde, L. Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid
medications and the risk of fracture. _Calcif. Tissue Int._ 79, 76–83 (2006). Article CAS PubMed Google Scholar * Targownik, L. E. _ et al_. Use of proton pump inhibitors and risk of
osteoporosis-related fractures. _CMAJ_ 179, 319–326 (2008). Article PubMed PubMed Central Google Scholar * Corley, D. A. Proton pump inhibitors, H2 antagonists, and risk of hip fracture:
a large population-based study [abstract]. Presented at Digestive Disease Week 2009. _Gastroenterology_ 136, A70 (2009). Article Google Scholar * Recker, R. R. Calcium absorption and
achlorhydria. _N. Engl. J. Med._ 313, 70–73 (1985). Article CAS PubMed Google Scholar * O'Connell, M. B., Madden, D. M., Murray, A. M., Heaney, R. P. & Kerzner, L. J. Effects of
proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. _Am. J. Med._ 118, 778–781 (2005). Article CAS PubMed Google Scholar * Bo-Linn, G. W. _ et
al_. An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium. _J. Clin. Invest._ 73, 640–647 (1984). Article CAS PubMed PubMed Central Google
Scholar * Yu, E. W. _ et al_. Acid-suppressive medications and risk of bone loss and fracture in older adults. _Calcif. Tissue Int._ 83, 251–259 (2008). Article CAS PubMed PubMed Central
Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Division of Internal Medicine, Section of Gastroenterology, University of Manitoba, Winnipeg, MB, Canada
Laura E. Targownik Authors * Laura E. Targownik View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Laura E.
Targownik. ETHICS DECLARATIONS COMPETING INTERESTS L. E. Targownik has received honoraria from and acted as a consultant for AstraZeneca Canada. RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Targownik, L. Another bad break for proton-pump inhibitors?. _Nat Rev Rheumatol_ 5, 478–480 (2009). https://doi.org/10.1038/nrrheum.2009.176
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