Play all audios:
Access through your institution Buy or subscribe Analgesic medications are widely used, with aspirin, acetominophen and ibuprofen representing the three most commonly used prescription and
over-the-counter drugs. In fact, a US national survey showed that nearly 30% of participants aged 57–85 years take aspirin. However, these drugs also have effects on other systems—for
example, the well-documented protective effect of aspirin in cardiovascular disease, and the anticancer effect of aspirin and other NSAIDs, which is thought to be mediated by cyclooxygenase
2 inhibition, reduced inflammation and effects on cell proliferation and apoptosis. Contrary to this hypothesis though, is the suggestion that analgesic use may actually be associated with
an increased risk of cancer. This association has previously been investigated using case-control studies, but a team from the USA has now carried out two large prospective studies to
examine the use of analgesics with regard to risk of renal cell carcinoma (RCC). The results were published in _Archives of Internal Medicine_. This is a preview of subscription content,
access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn
more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS
OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Cho, E. _ et al_. Prospective evaluation of analgesic use and
risk of renal call cancer. _Arch. Intern. Med._ 171, 1487–1493 (2011) Article PubMed PubMed Central Google Scholar Download references Authors * Annette Fenner View author publications
You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Fenner, A. Long-term use of nonaspirin NSAIDs
increases RCC risk. _Nat Rev Urol_ 8, 590 (2011). https://doi.org/10.1038/nrurol.2011.148 Download citation * Published: 04 October 2011 * Issue Date: November 2011 * DOI:
https://doi.org/10.1038/nrurol.2011.148 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative