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Comparative analysis of 51 long-term survivors of childhood acute lymphoblastic leukemia and 56 age-matched controls has revealed that treatment with 0–10 g/m2 cyclophosphamide or cranial
irradiation does not affect fertility or semen quality later in life. Notably, cylosphosphamide—but not cranial irradiation—was associated with lower testosterone levels (213 pmol/l versus
296 pmol/l in controls), and testicular size was found to predict nonazoospermic semen samples better than serum inhibin B level. ORIGINAL RESEARCH PAPER * Jahnukainen, K. _ et al_. Semen
quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia. _Fertil. Steril._ 96, 837–842 (2011) Article PubMed Google Scholar Download references RIGHTS
AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Long-term effects of childhood leukemia treatment. _Nat Rev Urol_ 8, 646 (2011).
https://doi.org/10.1038/nrurol.2011.170 Download citation * Published: 08 November 2011 * Issue Date: December 2011 * DOI: https://doi.org/10.1038/nrurol.2011.170 SHARE THIS ARTICLE Anyone
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