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Access through your institution Buy or subscribe Development of new nerve fibres (neoneurogenesis) might serve a similar purpose to neoangiogenesis in prostate cancer, according to new
research published in _Science_. “We have described, for the first time, neonerves growing around and inside the tumour and shown that these nerves affect the behaviour of prostate cancer,”
explains Paul Frenette, of the Albert Einstein College of Medicine, New York. Following on from these findings, researchers assessed adrenergic and cholinergic nerve densities in a cohort of
43 men with untreated prostate cancer. They found that adrenergic fibres densely innervated normal prostate tissue surrounding the tumour, whereas cholinergic fibres infiltrated the tumour
itself. Moreover, nerve fibre density was found to correlate positively with preoperative PSA, time to biochemical recurrence and extraprostatic extension in preliminary analyses. This is a
preview of subscription content, access via your institution RELEVANT ARTICLES Open Access articles citing this article. * CHRONIC NEURAL ACTIVITY RECORDED WITHIN BREAST TUMORS * Grant A.
McCallum * , Jay Shiralkar * … Dominique M. Durand _Scientific Reports_ Open Access 09 September 2020 ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12
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RESEARCH PAPER * Magnon, C. _ et al_. Autonomic nerve development contributes to prostate cancer progression. _Science_ doi:10.1126/science.1236361 Download references Authors * Sarah Payton
View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Payton, S. A role
for neoneurogenesis in tumour progression?. _Nat Rev Urol_ 10, 491 (2013). https://doi.org/10.1038/nrurol.2013.166 Download citation * Published: 30 July 2013 * Issue Date: September 2013 *
DOI: https://doi.org/10.1038/nrurol.2013.166 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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