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Access through your institution Buy or subscribe Antimuscarinics have been the standard-of-care pharmacological approach for the noninvasive management of patients with a range of storage
lower urinary tract symptoms (LUTS) for several decades. However, despite these agents being effective in most patients, the adverse event profile often precludes long-term use. In 2012, the
FDA approved the β3-adrenoceptor agonist mirabegron for the treatment of overactive bladder syndrome. Treatment with this agent results in fewer, and better-tolerated adverse events than
treatment with antimuscarinics. However, some urologists remain sceptical about the efficacy of mirabegron. This is a preview of subscription content, access via your institution ACCESS
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institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Imamura, T. _ et al_. Combined treatment with a β3-adrenergic receptor agonist and a muscarinic receptor
antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats. _Neurourol. Urodyn._ http://dx.doi.org/10.1002/nau.23061 (2016) * Wada, N. _ et al_.
Combinational effects of muscarinic receptor inhibition and β3-adrenoceptor stimulation on neurogenic bladder dysfunction in rats with spinal cord injury. _Neurourol. Urodyn._
http://dx.doi.org/10.1002/nau.23066 (2016) Download references Authors * Peter Sidaway View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sidaway, P. β3-adrenoceptor agonists synergize with antimuscarinics. _Nat Rev Urol_ 13, 496 (2016).
https://doi.org/10.1038/nrurol.2016.137 Download citation * Published: 19 July 2016 * Issue Date: September 2016 * DOI: https://doi.org/10.1038/nrurol.2016.137 SHARE THIS ARTICLE Anyone you
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