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Access through your institution Buy or subscribe In _S. cerevisiae_, each of the two chromosomal loci, dubbed HML and HMR, contain silencing elements bound by the replication complex ORC.
Four silent information regulator (ySir) proteins are also needed to silence these chromosomal regions; ySir2p is an NAD-dependent histone deacetylase, while ySir3p and ySir4p bind to
histone tails lacking acetyl groups. Efficient silencing may thus involve recruitment of ySir2p and histone deacetylation, which lowers gene expression and nucleates a ySir3p/ySir4p
repressive structure. Similar processes underlie silencing at telomeres. But how is it that silencing contained at mating loci, while it spreads at regions bordering telomeres? ORC may
provide a clue, as the yeast Orc1 (yOrc1) protein subunit can bind directly to ySir1p _via_ its N-terminal domain (NTD). Recruitment of ySir1p to the HML and HMR silencer elements _via_ the
ORC complex could thus bring about binding of the remaining Sir proteins and strengthen their association with the mating loci. This is a preview of subscription content, access via your
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* Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Andreas G. Ladurner View author publications You can also search for this author inPubMed
Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ladurner, A. The origin of silence. _Nat Struct Mol Biol_ 9, 718 (2002).
https://doi.org/10.1038/nsb1002-718 Download citation * Issue Date: 01 October 2002 * DOI: https://doi.org/10.1038/nsb1002-718 SHARE THIS ARTICLE Anyone you share the following link with
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