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Access through your institution Buy or subscribe A recent study (Pease _et al_., _Science_ 307, 586–590, 2005) has uncovered interesting new facets of the movement of FtsK on the DNA. This
single molecule study confirms that FtsK is the premier speedster of the cell. It translocates along DNA at rates of up to 5 kb per second without unwinding the DNA—making FtsK the fastest
motor protein yet identified. It also has muscle, able to maintain high speed against significant load. FtsK was observed to move bidirectionally without losing contact with DNA, suggesting
that there is more than one motor in the complex (schematized as purple triangle and green square). While both motors seem to be capable of bidirectional movement, only one is active at a
time. This leads to accumulation of supercoiled DNA between the motors. For actual translocation to occur, the supercoiled DNA must be released through the rear motor (green square). This is
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during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support Authors * Angela K Eggleston View author publications
You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Eggleston, A. Hanging around at _dif_. _Nat
Struct Mol Biol_ 12, 216 (2005). https://doi.org/10.1038/nsmb0305-216 Download citation * Issue Date: 01 March 2005 * DOI: https://doi.org/10.1038/nsmb0305-216 SHARE THIS ARTICLE Anyone you
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